The object of this study is to evaluate the effects of current processes on the future of universities. A wide global view – including economic, academic, social and other aspects – is described, with special emphasis on Israeli issues. Due to significant changes in technology, society and business – combined forces are threating the future of universities. There is a common belief that these forces could result in – significant changes and disruption in historical scale. As a result – the universities will have to reinvent themselves once again.